指定課題研究報告
SERUM RESISTIN LEVELS IN PATIENTS WITH ADULT GROWTH HORMONE DEFICIENCY
Naomi Hizuka, Yukiko Ishikawa, Akira Sata, Izumi Fukuda, Makiko Kurimoto, Junko Tsukada, Yuko Murakami, Kumiko Yasumoto,Yumiko Okubo, Kazue Takano
Department of Medicine II, Tokyo Women's Medical University, Tokyo, 162-8666, Japan
AIM
Patients with adult growth hormone deficiency (GHD) have altered body composition, abnormal lipid profile, increased prevalence of athelosclerosis and impaired glucose tolerance. One of the possible mechanism of these abnormalities is an increase of insulin resistance that might be related to increased body fat with abdominal preponderance. Increased resistin secreted from fat cells might cause insulin resistance in these patients.
In the present study, we measured serum resistin levels in patients with GHD and investigated the relationship between the resistin levels and the values of homeostasis model assessment of insulin resistance (HOMA-R).
SUBJECTS AND METHODS
Thirty-six patients with GHD (M/F:16/20) with a mean age of 44.2±3.0 (12~76) yrs and 65 control subjects (M/F:37/28) with a mean age of 43.1±1.8 (22~77) yrs were studied.
Serum resistin levels were measured by ELISA (BioVendor Laboratory Medicine, Inc.). The insulin resistance and sensitivity were assessed by homeostasis model assessment of insulin resistance (HOMA-R) and quantitative insulin sensitivity check index (QUICKI), respectively.
RESULTS
HOMA-R values in GHD were 2.80 ± 0.43. The values were significantly greater than those in control subjects (1.46 ± 0.09; P<0.0001), suggesting that the patients with GHD had insulin resistance.
Serum resistin levels in patients with GHD ranged from 1.3 to 24.5, with a mean of 6.6± 0.7 ng/ml. The values were higher than those in controls (4.0±0.2ng/ml; P<0.0001). The resistin levels did not correlate with HOMA-R and BMI.
CONCLUSIONS
These results suggest that serum resistin levels and insulin resistance are increased in GHD. The resistin levels did not correlated with the index of insulin resistance, however, the increased resistin values might play some roles in prevalence of impaired glucose tolerance in GHD.