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SERUM ADIPONECTIN LEVELS IN PATIENTS WITH GROWTH HORMONE DEFICIENCY

Naomi Hizuka, Izumi Fukuda, Yukiko Ishikawa, Emina Itoh, Yuko Murakami, Akira Sata, Junko Tsukada, Kumiko Yasumoto, Makiko Kurimoto, Yumiko Okubo, Kazue Takano
Department of Medicine II, Tokyo Women's Medical University, Tokyo, 162-8666, Japan

AIM

@@Adiponectin, an adipocyte-derived plasma protein with insulin-sensitizing and antiatherosclerotic properties, has been found to be a negative regulator of insulin resistance in obese patients. Patients with adult growth hormone deficiency (GHD) have been found to have increased body fat with abdominal preponderance, prevalence of premature atherosclerosis, and mortality from cardiovascular disease. It has been suggested that the insulin resistance might play some role in these pathogenesis. Therefore, we measured serum adiponectin levels in patients with GHD, and investigated the relationship between the adiponectin and insulin resistance in these patients.

SUBJECTS AND METHODS

@@Thirty-five patients with GHD (M/F: 16/19) with a mean (} SD) of age of 43.8} 19.0 yrs and twenty-five normal subjects (M/F: 12/13) with a mean age of 44.4}12.4 yrs were studied.
@@Serum adiponectin levels were measured by RIA (LINCO Research, Inc). The insulin resistance and sensitivity were assessed by homeostasis model assessment of insulin resistance (HOMA-R) and quantitative insulin sensitivity check index (QUICKI), respectively.

RESULTS

@@Serum adiponectin levels in patients with GHD ranged from 2.07 to 16.45 (Median: 4.54), with a mean (} SEM) of 6.17}0.65 ƒĘg/ml. The values were lower than normal subjects (Median: 6.35, Mean } SEM: 7.80 } 0.86 ƒĘg/ml), but not significant (P=0.099). The body mass index (BMI) in patients with GHD were significantly greater than those in normal subjects (23.5}0.7 vs 20.6}0.4, P<0.005). The adiponectin levels in patients with GHD correlated inversely with BMI in these subjects (R= -0.38, P<0.05) as same as in normal subjects (R= -0.4, P<0.05). The HOMA-R and QUICKI in patients with GHD significantly differed from those in normal subjects (2.87}0.38 vs 1.44}0.07, P<0.03; 0.342}0.006 vs 0.363}0.002, P<0.03, respectively), suggesting insulin resistance in the GHD.
The serum adiponectin levels correlated inversely with HOMA-R (R=-0.48; P<0.01) and positively with QUICKI (R=0.48; P<0.01) in patients with GHD (Fig. 1).

CONCLUSIONS

@@These data demonstrate that serum adiponectin levels inversely correlated with BMI in the patients with GHD as well as normal subjects, and the adiponectin might be related with insulin resistance in patients with GHD.

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